LC -MS/MS STUDY OF THE TRACE LEVEL IMPURITIES OF IRBESARTAN AN ANGIOTENSIN II RECEPTOR ANTAGONIST MOLECULE TO ITS ORIGIN THROUGH n MS
By: Saravanan, S
.
Contributor(s): Ansari, A. Taminum.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(1).Description: 38-43p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
The
mass characteriz
ation
of five
trace level related impurities of Irbesartan was performed through the “nMS2” technique of triple
quadrupole mass spectrometer and also to
Correlated
to the impurity origin.
Method
s:
A simple
& effective
patented process was applied to get the impurity profile,
and
mass
characteri
zation
was performed through the
“nMS2” technique of triple quadrupole
mass
spectrometer
analyser.
Result
s:
The simple production scan in differential collision energies is coined as “nMS2” technique of the triple quadrupole analyzer.
The
molecular ion fragmentation occurs with multiple collision energies
and
provides meaningful MSMS fragments for characterizing
five trace l
evel
impurities less than 0.5%
of angiotensin II receptor antagonist
-Irbesartan
. Th
e origin of the impurity formation in the synthetic process was
successfully
related to the
Spiro ketones.
Conclusio
n:
The results obtained in this research clearly indicates the approach of “nM
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020934 |
Objective:
The
mass characteriz
ation
of five
trace level related impurities of Irbesartan was performed through the “nMS2” technique of triple
quadrupole mass spectrometer and also to
Correlated
to the impurity origin.
Method
s:
A simple
& effective
patented process was applied to get the impurity profile,
and
mass
characteri
zation
was performed through the
“nMS2” technique of triple quadrupole
mass
spectrometer
analyser.
Result
s:
The simple production scan in differential collision energies is coined as “nMS2” technique of the triple quadrupole analyzer.
The
molecular ion fragmentation occurs with multiple collision energies
and
provides meaningful MSMS fragments for characterizing
five trace l
evel
impurities less than 0.5%
of angiotensin II receptor antagonist
-Irbesartan
. Th
e origin of the impurity formation in the synthetic process was
successfully
related to the
Spiro ketones.
Conclusio
n:
The results obtained in this research clearly indicates the approach of “nM
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